Isolation and Characterization of Neuroprotective Components from Citrus Peel and Their Application as Functional Food

The elderly experience numerous physiological alterations. In the brain, aging causes degeneration or loss of distinct populations neurons, resulting in declining cognitive function, locomotor capability, etc. pathogenic factors such neurodegeneration are oxidative stress, mitochondrial dysfunction, inflammation, reduced energy homeostatis, decreased levels neurotrophic factor, On other hand, studies have investigated various biologically active substances fruit and vegetables. We focused on peel citrus to search for neuroprotective components found that: 1) 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF) auraptene (AUR) Kawachi Bankan (Citrus kawachiensis) exert effects; 2) both HMF AUR can pass through blood–brain barrier, suggesting that they act directly brain; 3) content K. was exceptionally high, consequently oral administration dried powder exerts 4) intake juice, which enriched by adding paste raw contributed prevention dysfunction aged healthy volunteers. This review summarizes our terms isolation/characterization peel, analysis their actions mechanisms actions, trials develop food retains functions.